Yayınlar
2024
Adan, A. DNA Methylation Alterations in Acute Myeloid Leukemia: Therapeutic Potential. In: Hematological Cancer Diagnosis and Treatment: An Interdisciplinary Approach. Springer, Cham. 2024. ISBN: 978-3-031-75448-7. doi:10.1007/16833_2023_192.
Uçar Akyürek T, Orhan IE, Şenol Deniz FS, Eren G, Acar B, Sen A. Evaluation of Selected Plant Phenolics via Beta-Secretase-1 Inhibition, Molecular Docking, and Gene Expression Related to Alzheimer’s Disease. Pharmaceuticals. 2024; 17(11):1441. doi.org/10.3390/ph17111441.
Yilmaz A, Koca M, Ercan S, Acar OO, Boga M, Sen A, Kurt A. Amelioration potential of synthetic oxime chemical cores against multiple sclerosis and Alzheimer's diseases: Evaluation in aspects of in silico and in vitro experiments. J. Mol. Struct. Volume 1318, Part 1, 15 December 2024, 139193. doi.org/10.1016/j.molstruc.2024.139193.
Gencer Akçok EB, Güner H, Akçok İ. Determination of promising inhibitors for N-SH2 domain of SHP2 tyrosine phosphatase: an in silico study. Mol Divers. 2024 May 13. doi: 10.1007/s11030-024-10880-2.
Ayvaz HB, Yenigül M, Gencer Akçok EB. Tomatidine, a Steroidal Alkaloid, Synergizes with Cisplatin to Inhibit Cell Viability and Induce Cell Death Selectively on FLT3-ITD+ Acute Myeloid Leukemia Cells. Cell Biochem Biophys. 2024 Jul 11. doi: 10.1007/s12013-024-01406-6.
Pir MS, Begar E, Yenisert F, Demirci HC, Korkmaz ME, Karaman A, Tsiropoulou S, Firat-Karalar EN, Blacque OE, Oner SS, Doluca O, Cevik S, Kaplan OI. CilioGenics: an integrated method and database for predicting novel ciliary genes. Nucleic Acids Res. Published online July 11, 2024. doi:10.1093/nar/gkae554.
Tecik M, Adan A. Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors. Curr. Treat. Options in Oncol. 2024. https://doi.org/10.1007/s11864-024-01202-7.
Şansaçar M, Sağır H, Gencer Akçok EB. Inhibition of PI3K-AKT-mTOR pathway and modulation of histone deacetylase enzymes reduce the growth of acute myeloid leukemia cells. Med Oncol. 2024. https://doi.org/10.1007/s12032-023-02247-8.
Şansaçar M, Gencer Akçok EB. Measurement of Autophagic Activity in Cancer Cells with Flow Cytometric Analysis Using Cyto-ID Staining. Methods Mol Biol. 7 Mart 2024. https://doi.org/10.1007/7651_2024_526.
2023
Bay ÖF, Hayes KS, Schwartz, JM, Grencis RK, Roberts IS. A genome-scale metabolic model of parasitic whipworm. Nat Commun. 2023;14(1):6937. https://doi.org/10.1038/s41467-023-42552-4.
Vasilopoulos SN, Güner H, Uça Apaydın M, Pavlopoulou A, Georgakilas AG. Dual Targeting of DNA Damage Response Proteins Implicated in Cancer Radioresistance. Genes. 2023, 14, 2227. https://doi.org/10.3390/genes14122227.
Şaylan D, Cebeci F. Isothiocyanates as Drug Candidates in Cancer Prevention and Treatment (Book Chapter, 22 - 60). Multidisciplinary Applications of Natural Science for Drug Discovery and Integrative Medicine, ABD: IGI Global, 05 Mayıs 2023. ISBN: 9781668494639.
Şaylan D, Erdem İ. Metal Nanoparticles via Green Synthesis: A New Cancer Treatment Approach (Book Chapter). Cutting-Edge Applications of Nanomaterials in Biomedical Sciences. ABD: IGI Global, 2023. https://doi.org/10.4018/979-8-3693-0448-8.
Gunalp S, Helvaci DG, Oner A, Bursalı A, Conforte A, Güner H, Karakülah G, Szegezdi E, Sag D. TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content. Front Immunol. 2023;21;14:1209249. doi: 10.3389/fimmu.2023.1209249.
Cevik S, Peng X, Beyer T, Pir MS, Yenisert F, Woerz F, Hoffmann F, Altunkaynak B, Pir B, Boldt K, Karaman A, Cakiroglu M, Oner SS, Cao Y, Ueffing M, Kaplan OI. WDR31 displays functional redundancy with GTPase-activating proteins (GAPs) ELMOD and RP2 in regulating IFT complex and recruiting the BBSome to cilium. Life Sci Alliance. 2023;19;6(8):e202201844. doi: 10.26508/lsa.202201844.
Cevik S, Zhao P, Zorluer A, Pir MS, Bian W, Kaplan OI. Matching variants for functional characterization of genetic variants. G3 (Bethesda). 2023;jkad227. doi: 10.1093/g3journal/jkad227.
Turan MG, Orhan ME, Cevik S, Kaplan OI. CiliaMiner: an integrated database for ciliopathy genes and ciliopathies. Database (Oxford). 2023;26;2023:baad047. doi: 10.1093/database/baad047.
Yenigül M, Gencer Akcok EB. Histone Deacetylase Inhibition and Autophagy Modulation Induces a Synergistic Antiproliferative Effect and Cell Death in Cholangiocarcinoma Cells. ACS Omega. 2023;8(24):21755-21768. doi:10.1021/acsomega.3c01317.
Senol, H, Celik-Turgut G, Sen A, Saglamtas R, Tuncay S, Gulcin I, Topcu G. Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors. Med Chem Res. 2023. doi:10.1007/s00044-023-03031-z.
Celik-Turgut G, Olmez N, Koc T, Ozgun-Acar O, Semiz A, Dodurga Y, Lale Satiroglu-Tufan N, Sen A. Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells. Gene. 2023;853:147099. doi:10.1016/j.gene.2022.147099.
Senol H, Ozgun-Acar O, Dağ A, Eken A, Guner H, Aykut ZG, Topcu G, Sen A. Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent. J Nat Prod. 2023;86(1):103-118. doi:10.1021/acs.jnatprod.2c00798.
2022
Erdogan Orhan I, Deniz FSS, Salmas RE, Irmak S, Acar OO, Turgut GC, Sen A, Zbancioc AM, Luca SV, Skiba A, Skalicka-Woźniak K, Tataringa G. Evaluation of Anti-Alzheimer Activity of Synthetic Coumarins by Combination of in Vitro and in Silico Approaches. Chem Biodivers. 2022;19(12):e202200315. doi:10.1002/cbdv.202200315.
Ozgun-Acar O, Celik-Turgut G, Guner H, Sezer S, Sen A. Biochemical, pharmacological, and toxicological attributes of caper (Capparis ovata) flowering buds and berries pickles. Food Sci Nutr. 2022;10(12):4189-4200. Published 2022 Jul 30. doi:10.1002/fsn3.3012.
Acar MB, Ayaz-Guner S, Guner H, Dinc G, Ulu Kılıc A, Doganay M, Ozcan S. A subtractive proteomics approach for the identification of immunodominant Acinetobacter baumannii vaccine candidate proteins. Front Immunol. 2022;13:1001633. Published 2022 Nov 10. doi:10.3389/fimmu.2022.1001633.
Sulak M, Turgut GC, Sen A. Cerium Oxide Nanoparticles Biosynthesized Using Fresh Green Walnut Shell in Microwave Environment and their Anticancer Effect on Breast Cancer Cells. Chem Biodivers. 2022;19(8):e202200131. doi:10.1002/cbdv.202200131.
Sen A. Complementary medicines used in ulcerative colitis and unintended interactions with cytochrome P450-dependent drug-metabolizing enzymes. Turk J Med Sci. 2022;52(5):1425-1447. doi:10.55730/1300-0144.5482.
Pir MS, Cevik S, Kaplan OI. ConVarT: Search Engine for Missense Variants Between Humans and Other Organisms. Curr Protoc. 2022;2(11):e619. doi:10.1002/cpz1.619.
Pir MS, Bilgin HI, Sayici A, Coşkun F, Torun FM, Zhao P, Kang Y, Cevik S, Kaplan OI. ConVarT: a search engine for matching human genetic variants with variants from non-human species. Nucleic Acids Res. 2022;50(D1):D1172-D1178. doi:10.1093/nar/gkab939.
Turan MG, Kantarci H, Temtek SD, Cakici O, Cevik S, Kaplan OI. Protocol for determining the average speed and frequency of kinesin and dynein-driven intraflagellar transport (IFT) in C. elegans. STAR Protoc. 2022;3(3):101498. doi:10.1016/j.xpro.2022.101498.
Cicek E, Kucuktas FM, Yenigul M, Gencer Akcok EB. Cytotoxic and cytostatic effects of targeting mTOR and Hedgehog pathways in acute myeloid leukemia. Experimed. 2022. doi: 10.26650/experimed.1193721.
Sansacar M, Sagir H, Gencer Akcok EB. AML-240: Investigation of the Antitumor Effect of Targeting PI3K-AKT-mTOR Pathway and Histone Deacetylase Enzymes on Acute Myeloid Leukemia Cells. Clin Lymphoma Myeloma Leuk. 2022. doi:10.1016/S2152-2650(21)01702-X.
Tecik M, Adan A. Therapeutic Targeting of FLT3 in Acute Myeloid Leukemia: Current Status and Novel Approaches. Onco Targets Ther. 2022. doi:10.2147/OTT.S384293.
Yenigül M, Akçok İ, Gencer Akçok EB. Ethacrynic acid and cinnamic acid combination exhibits selective anticancer effects on K562 chronic myeloid leukemia cells. Mol Biol Rep. 2022. doi:10.1007/s11033-022-07560-5.
Ersöz NŞ, Adan A. Differential in vitro anti-leukemic activity of resveratrol combined with serine palmitoyltransferase inhibitor myriocin in FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) carrying AML cells. Cytotechnology. 2022. doi.org/10.1007/s10616-022-00527-1.
Sahin HN, Adan A. Combined effect of midostaurin and sphingosine kinase-1 inhibitor on FMS-like tyrosine kinase 3 (FLT3) wild type acute myeloid leukemia cells. Turkish J. Biochem. 2022. doi.org/10.1515/tjb-2021-0152.
Ersöz NŞ, Adan A. Resveratrol triggers anti-proliferative and apoptotic effects in FLT3-ITD-positive acute myeloid leukemia cells via inhibiting ceramide catabolism enzymes. Med. Oncol. 2022;39(35):1-13. doi.org/10.1007/s12032-021-01627-2.
2021
Yenigül M, Gencer Akcok EB. The therapeutic potential of targeting HDAC6 with Tubastatin A in TFK-1 and EGI-1 cholangiocarcinoma cells. Cumhuriyet Sci. J. 2021;42(4):775-780. doi.org/10.17776/csj.963107.
Kavakcioglu Yardimci B, Ozgun-Acar O, Semiz A, Sen A. Apatinib Sensitizes Human Breast Cancer Cells against Navitoclax and Venetoclax Despite Up-regulated Bcl-2 and Mcl-1 Gene Expressions. Turkish Journal of Oncology.2021;36(1):8-16. doi:10.5505/tjo.2020.2380.
Hitit M, Özbek M, Ayaz-Guner S, Guner H, Oztug M, Bodu M, Kirbas M, Bulbul B, Bucak MN, Ataman MB, Memili E, Kaya A. Proteomic fertility markers in ram sperm. Anim Reprod Sci. 2021;235:106882. doi:10.1016/j.anireprosci.2021.106882.
Şahin HN, Adan A. Glucosylceramide Synthase Is a Novel Biomarker of Midostaurin-Induced Cytotoxicity in Non-Mutant FLT3 Positive Acute Myeloid Leukemia Cells. Experimed. 2021;11(3):149-55. doi: 10.26650/experimed.2021.974943.
Oğuz O, Adan A. Involvement of Sphingolipid Metabolism Enzymes in Resveratrol-Mediated Cytotoxicity in Philadelphia-Positive Acute Lymphoblastic Leukemia. Nutr Cancer. 2021;1-14. doi: 10.1080/01635581.2021.2005806.
Acar MB, Ayaz-Guner S, Gunaydin Z, Karakukcu M, Peluso G, Di Bernardo G, Ozcan S, Galderisi U. Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells. Frontiers in Bioengineering and Biotechnology. 2021;9;10.3389/fbioe.2021.730813. doi: 10.3389/fbioe.2021.730813.
Cevik S, Kaplan OI. The Joubert syndrome protein CEP41 is excluded from the distal segment of cilia in C. elegans. MicroPubl Biol. 2021;2021:10.17912/micropub.biology.000406. doi: 10.17912/micropub.biology.000406.
Cevik S, Kaplan OI. Subcellular localization of the voltage-gated K+ channel EGL-36 , a member of the KV3 subfamily, in the ciliated sensory neurons in C. elegans. MicroPubl Biol. 2021;2021:10.17912/micropub.biology.000367. doi: 10.17912/micropub.biology.000367.
Acar MB, Aprile D, Ayaz-Guner S, Guner H, Tez C, Di Bernardo G, Peluso G, Ozcan S, Galderisi U. Why Do Muse Stem Cells Present an Enduring Stress Capacity? Hints from a Comparative Proteome Analysis. International Journal of Molecular Sciences. 2021; 22(4):2064. doi: 10.3390/ijms22042064.
2020
Ersöz NŞ, Adan A. Cytotoxic Effects of Resveratrol and Its Combinations with Ceramide Metabolism Inhibitors on FLT3 Positive Acute Myeloid Leukemia. Erzincan University Journal of Science and Technology. 2020;13(3):1205-1216. doi: 10.18185/erzifbed.764085.
Acar MB, Ayaz-Güner S, Di Bernardo G, Güner H, Murat A, Peluso G, Özcan S, Galderisi U. Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue. Aging (Albany NY). 2020;12:10.18632/aging.202423. doi: 10.18632/aging.202423.
Gazioglu I, Semen S, Acar OO, Kolak U, Sen A, Topcu G. Triterpenoids and steroids isolated from Anatolian Capparis ovata and their activity on the expression of inflammatory cytokines. Pharm Biol. 2020;58(1):925-931. doi: 10.1080/13880209.2020.1814356.
Semiz, A., Ozgun Acar, O., Cetin, H., Semiz, G., & Sen, A. Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis. Journal of Translational Internal Medicine. 2020;8(3):177-187. doi: 10.2478/jtim-2020-0027.
Ercan A. Sex effect on the correlation of immunoglobulin G glycosylation with rheumatoid arthritis disease activity. Turk J Biol. 2020;44(6):406-416. doi: 10.3906/biy-2005-7.
Sen A. Prophylactic and therapeutic roles of oleanolic acid and its derivatives in several diseases. World J Clin Cases. 2020;8(10):1767-1792. doi: 10.12998/wjcc.v8.i10.1767.
Ayaz-Guner S, Alessio N, Acar MB, et al. A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions. Cell Commun Signal. 2020;18(1):118. doi: 10.1186/s12964-020-00614-w.
Saçar Demirci MD, Adan A. Computational analysis of microRNA-mediated interactions in SARS-CoV-2 infection. PeerJ. 2020;8:e9369. doi: 10.7717/peerj.9369.
2019
Brown KA, Chen B, Guardado-Alvarez TM, Lin Z, Ayaz-Guner S, Jin S, Ge Y. A photocleavable surfactant for top-down proteomics. Nat Methods. 2019;16(5):417-420. doi: 10.1038/s41592-019-0391-1.
Sen A, Stark H. Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis. World J Gastroenterol. 2019;25(23):2846-2862. doi: 10.3748/wjg.v25.i23.2846.
Sen A, Ayar B, Yılmaz A, Acar Ö, Turgut G, Topçu G. Natural diterpenoid alysine A isolated from Teucrium alyssifolium exerts antidiabetic effect via enhanced glucose uptake and suppressed glucose absorption. Turk J Chem. 2019; 43(5): 1350-1364.
Ege T, Ozkan AMG, Sen A, Adali O. Evaluation of in vivo effects of Viscum album l. and its constituent o-coumaric acid on bile acid synthesizing CYPs. FEB. 2019;28(4): 2825-2834.
2018
Gül Amuk N, Kurt G, Kartal Yandim M, Adan A, Baran Y. A minimally invasive transfer method of mesenchymal stem cells to the intact periodontal ligament of rat teeth: a preliminary study. Turk J Biol. 2018;42(5):382-391.
Adan A. Kanserde Sfingolipidler (Kitap Bölümü), Kanser Moleküler Biyolojisi, Kısayol Yayıncılık. 2018; ISBN: 978-605-2329-28-3.
Adan A, Oguz O. Pleiotropic Molecular Effects of Dietary Polyphenols Resveratrol and Apigenin in Leukemia, Book Chapter in Polyphenols in Human Health and Disease, Elsevier. 2018; ISBN: 978-0123984562.
Martin-Garrido A, Biesiadecki BJ, Salhi HE, Shaifta Y,Dos Remedios CG, Ayaz-Guner S, Cai W, Ge Y, Avkiran M, Kentish JC. Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis. J Biol Chem. 2018;293(22):8588-8599.
2017
Adan A, Alizadeh G, Kiraz Y, Nalbant A, Baran Y. Flow cytometry: Basic Principles and Applications. 2017, Critical Reviews in Biotechnology.
Amuk NG, Kurt G, Baran Y, Seyrantepe V, Kartal-Yandim M, Adan A, Sönmez MF. Effects of Cell-Mediated Osteoprotegerin Gene Transfer and Mesenchymal Stem Cell Applications on Orthodontically Induced Root Resorption of Rat Teeth, In Press, 2017, European Journal of Orthodontics.
Işık S, Uzuner N, Karaman M, Karaman Ö, Kıray M, Kozanoğlu İ, Bağrıyanık HA, Arıkan-Ayyıldız Z, Kartal Yandım M, Baran Y. Potent effects of mesenchymal stem cells on murine model of bronchiolitis obliterans. Iranian Journal of Allergy, Asthma and Immunology, 2017; 16(3), 205-218.
Apohan E, Yilmaz U, Yilmaz O, Serindag A, Kucukbay H, Yesilada O, Baran Y. Synthesis, Cytotoxic and Antimicrobial Activities of Novel Cobalt and Zinc Complexes of Benzimidazole Derivatives. Journal of Organometallic Chemistry, 2017; 828, 52-58.
Işık S, Karaman M, Adan A, Kıray M, Bağrıyanık HA, Sözmen ŞÇ, Kozanoğlu İ, Karaman Ö, Baran Y, Uzuner N. Intraperitoneal Mesenchymal Stem Cell Administration Ameliorates Allergic Rhinitis in the Murine Model. European Archives of Oto-Rhino-Laryngology and Head & Neck, 2017; 274, 197-207.
2016
Adan A, Kiraz Y, Baran Y. Cell Proliferation And Cytotoxicity Assays. Current Pharmaceutical Biotechnology, 2016; 17(14): 1213-1221
Kiraz Y, Neergheen-Bhujun VS, Rummun N, Baran Y. Apoptotic Effects Of Non-Edible Parts Of Punica Granatum On Human Multiple Myeloma Cells. Basım Aşamasında, 2016, Tumor Biology.
Yandim MK, Ceylan C, Elmas E, Baran Y. A molecular and biophysical comparison of macromolecular changes in imatinib-sensitive and imatinib-resistant K562 cells exposed to ponatinib. Basım Aşamasında, 2016, Tumor Biology.
Adan A, Baran Y. Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling. Basım Aşamasında, 2016, Tumor Biology.
Nalbant A, Kiraz Y, Baran Y. T cells in Tumor Microenvironment. Basım Aşamasında, 2016, Tumor Biology.
Adan A, Alizada G, Kiraz Y, Nalbant A, Baran Y. Flow cytometry: Basic principles and applications. Basım Aşamasında, 2016, Critical Reviews in Biotechnology.
Kiraz Y, Adan A, Kartal Yandim M, Baran Y. Major apoptotic mechanisms and genes involved in apoptosis. Basım Aşamasında, 2016, Tumor Biology.
Emmrich S., Engeland F., El-Khatib M., Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink MM, Klusmann JH. miR-139-5p controls translation in myeloid leukemia through EIF4G2, Oncogene, 2016, 35(14), 1822-31.
İ.A. İşoğlu, Y. Özsoy, S. Dinçer İşoğlu, Advances in micelle-based drug delivery: Cross-linked systems, Current Topics in Medicinal Chemistry, 2016, Doi: 10.2174/1568026616666161222110600.
K. Salimi, M. Topuzoğulları, S. Dinçer, H.M. Aydın, E. Pişkin, “Microwave-asisted green approach for graft copolymerization of L-lactic acid onto starch”, Journal of Applied Polymer Science, 2016, 133, 42937.
M. Topuzoğulları, Y. Basaran Elalmıs, S. Dinçer İşoğlu, Thermo-Responsive Complexes of c-Myc Antisense Oligonucleotide with Block Copolymer of Poly(OEGMA) and Quaternized Poly(4-Vinylpyridine). Macromolecular Bioscience, 2016, Doi: 10.1002/mabi.201600263.
2015
M. Kartal Yandım, A. Adan , Y. Baran. Molecular mechanisms of drug resistance and its reversal in cancer, Critical Reviews in Biotechnology. 2015, 24,1-11 (Epub ahead of print).
A. Adan, Y. Baran. A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells, Turkish Journal of Hematology, 2015, 32(2), 118-26.
M. Kartal Yandım, A. Adan, Y. Kiraz, Y. Baran. Rejenerative Medicine. Turkiye Klinikleri J Med Oncol-Special Topics, 2015, 8(2).
A. Adan, Y. Baran. The Pleiotropic Effects of Fisetin and Hesperetin on Human Acute Promyelocytic Leukemia Cells Are Mediated through Apoptosis, Cell Cycle Arrest and Alterations in Signaling Networks, Tumor Biology, 2015, 36(11),8973-84.
B. Tezcanlı Kaymaz, N. Selvi Günel, M. Ceyhan, V. Bozok Çetintaş, B. Özel, M. Kartal Yandım, S. Kıpçak, Ç. Aktan, A. Adan, Y. Baran, B. Kosova Can. Revealing Genome Wide mRNA and microRNA Expression Patterns in Leukemic Cells Highlighted "hsa-miR-2278" as a Tumor Suppressor for Regain of Chemotherapeutic İmatinib Response due to Targeting STAT5A. Tumor Biology, 2015, 36(10),7915-27.
A. Adan, Y. Baran. Fisetin and Hesperetin Induced Apoptosis and Arrested Cell Cycle in Chronic Myeloid Leukemia Cells Accompanied by Modulation of Cellular Signaling, Tumor Biology (Epub ahead of print).
A. Katgı, O.G. Sevindik, A. Adan, G.H. Ozsan, F. Yüksel, S.M. Solmaz, I. Alacıoğlu, M.A. Ozcan, F. Demirkan, Y. Baran, O. Pişkin. Nilotinib Does Not Alter the Secretory Functions of Carotid Artery Endothelial Cells in a Prothrombotic or Antithrombotic Fashion. Clin Appl Thromb Hemost, 2015, 21(7), 678-83
Kartal Yandım M, Adan Gokbulut A, Baran Y. Molecular Mechanisms of Drug Resistance and its Reversal in Cancer. Critical Reviews in Biotechnology, 2015; 24: 1-11.
Kaymaz BT, Günel NS, Ceyhan M, Çetintaş VB, Özel B, Yandım MK, Kıpçak S, Aktan Ç, Gökbulut AA, Baran Y, Can BK. Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted Bhsa-miR-2278 as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. Tumor Biology; 2015; 36(10): 7915-7927.
Adan A, Baran Y. The Pleiotropic Effects of Fisetin and Hesperetin on Human Acute Promyelocytic Leukemia Cells Are Mediated through Apoptosis, Cell Cycle Arrest and Alterations in Signaling Networks. Tumor Biology, 2015; 36(11): 8973-8984.
Mutlu P, Kiraz Y, Gündüz U, BaranY. An Update On Molecular Biology And Drug Resıstance Mechanısms Of Multıple Myeloma. Critical Reviews in Oncology/Hematology, 2015; 96(3): 413-424.
Cincin ZB, Unlu M, Kiran B, Bireller ES, Kiraz Y, Baran Y, Cakmakoglu B*. Anti-proliferative, apoptotic and signal transduction effects of hesperidin in non-small cell lung cancer cells. Cellular Oncology, 2015; 38(3): 195-204.
Cincin ZB, Unlu M, Kıran B, Bireller ES, Baran Y, Cakmakoglu B*. Apoptotic Effects of Quercitrin in DLD-1 Colon Cancer Cell Lines. Pathology and Oncology Research, 2015: 21; 333–338.
Tufekçi O, Yandim MK, Oren H, Irken G, Baran Y. Targeting FOXM1 Transcription Factor In T-Cell Acute Lymphoblastic Leukemia. Leukemia Research, 2015: 39(3); 342-347.
Baran Y. Kanserde İlaç Dirençliliği. Günce, Türkiye Bilimler Akademisi Dergisi, 2015; 48: 67-70.
Gokbulut AA, Baran Y. A Novel Natural Product, KL-21, Inhibits Proliferation and Induces Apoptosis in Chronic Lymphocytic Leukemia Cells. Turkish Journal of Hematology, 2015; 32(2): 118-26.
Katgı A*, Sevindik OG, Gokbulut AA, Ozsan HG, Yuksel F, Solmaz SM, Alacacıoglu I, Ozcan MA, Demirkan F, Baran Y, Piskin O. Nilotinib Does Not Alter the Secretory Funcions of Carotid Artery Endothelıal Cells in a Prothrombotic or Antithrombotic Fashion. Clinical and Applied Thrombosis/Hemostasis, 2015; 21(7): 678-83.
E. Kahraman, A. Karagöz, S. Dinçer İşoğlu, Y. Özsoy, “Polyethylenimine modified and non-modified polymeric micelles used for nasal administration of carvedilol (or medication)", Journal of Biomedical Nanotechnology, 2015, 11, 890-899.
S. Emmrich, F. Engeland, M. El-Khatib, K. Henke, J. E. Katsman-Kuipers, C. M. Zwaan, A. Pich, D. Reinhardt , M. W. J. Fornerod, M. M. van den Heuvel-Eibrink, J. H. Klusmann, miR-139-5p controls translation in myeloid leukemia through EIF4G2, Oncogene, 2015. (DOI: 10.1038/onc.2015.247)
J. J. Madsen, Y. Z. Ohkubo, G. H. Peters, J. H. Faber, E. tajkhorhsid, O. H. Olsen, Membrane interaction of the factor VIIIa discoidin domains in atomistic detail,Biochemistry, 2015, 54, 6123 (DOI: 10.1021/acs.biochem.5b00417)
Bildiriler
2024
N. Aktas Pepe, B. Acar, M. Sansacar, E. B. Gencer Akcok, A. Sen. The Effects of Cinnamic Acid and Autophagy Inhibition on Myelination of Co- cultured Cells. Posters. 12. International Drug Chemistry Conference, Antalya, Turkey, 7-10 March 2024, pp.84. Poster Bildirisi.
2023
D Saylan, DD Milanoviç, PD Jones. Glioblastoma Tedavisinde İtrakonozolün Bir Adjuvan Olarak Yeniden Konumlandırılması. 25. Ulusal Biyoloji Kongresi, 13 Temmuz 2023, 15 Aralık 2023, 115 - 115. Özet Bildiri.
F Cebeci, D Saylan. Bitkisel Kaynaklı Biyoaktif Bileşenlerin Kanser Üzerine Etkileri. 25. Ulusal Biyoloji Kongresi, 13 Temmuz 2023, 15 Aralık 2023, 116 - 116. Özet Bildiri.
S Sarı, PR Viciana. Assessing the Impact of Shoc2 on Hair Growth Cycle . 6th International Eurasian Conference on Biological and Chemical Sciences, 11-13 October 2023, pp.135.
S Sarı, ER Ozsoy. Exploring the Impact of Pan-AURKs and Selective AURKB Inhibitors on Non-Smal Cel Lung Cancer . 6th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Turkey, 11 -13 October 2023, pp.131.
S Sarı, PR Viciana. Analysis of Blood Chemistry Changes after Systemic SHOC2 Inactivation in Adult Mice. 6th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Turkey, 11 -13 October 2023, pp.302.
S Sarı, ER Ozsoy.The Role of Aurora Kinases in Human Colorectal Cancer. 6th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Turkey, 11 -13 October 2023, pp.130.
M Tecik, A Adan. Sphingosine 1-Phosphate Signaling in Midostaurin Resistance in FLT3-ITD Positive Acute Myeloid Leukemia. 3rd International Multidisciplinary Cancer Research Congress . 2023. (Özet Bildiri/Sözlü Sunum).
B. Acar, H. Stark, A. Sen. Investigating multitargeting effect offingolimod/ciproxifan butterfly derivatives formultiple sclerosis on brain organoids. Posters. FEBS Open Bio, 2023. 13:193. https://doi.org/10.1002/2211-5463.13646.
N. Aktas Pepe, T.N. Atalay, B. Acar, H. Senol, A. Sen. Investigating the anti-inflammatory activities of the new hybrid compound 4-((1-(3-nitrobenzyl)-4,5-dihydro-1H-1,2,3-triazol-4-yl)methoxy)benzohydrazide. Posters. FEBS Open Bio, 2023. 13: 103. https://doi.org/10.1002/2211-5463.13646.
2022
S Sarı, PR Viciana. Investigation of ex vivo Shoc2 Ablation in Murine Keratinocytes. 4th International Eurasian Conference on Science, Engineering and Technology, Ankara, Turkey, 14 -16 December 2022, pp. 206.
S Sarı, PR Viciana. Effect of Shoc2 Elimination in Urinary Bladder Function. 5th International Eurasian Conference on Biological and Chemical Sciences, Ankara, Turkey, 23 -25 November 2022, pp. 1706.
S Sarı, A Akarca, T Marafioti, PR Viciana. Physiological Role of Shoc2 in Skin Homeostasis Sarı S.,Akarca A., Marafioti T., Rodriguez-Viciana P. 5th International Eurasian Conference on Biological and Chemical Sciences, Ankara,Turkey, 23 -25 November 2022, pp.1707.
2021
Busra Acar, Nihan Aktas Pepe, Alaattin Sen. Optimization of myelination on human cerebral organoids for studying multiple sclerosis (MS). The EuroBiotech Journal Volume 5 Issue 3 Page 58. DOI: 10.2478/ebtj-2021-0030.
Atiyye Zorluer, Sebiha Cevik, Oktay I. Kaplan, Use of C. elegans for investigating functional consequence of orthologous variants, 23rd International C. elegans Conference, June 21-25, 2021.
Merve Gül Turan, Sebiha Cevik, Oktay I. Kaplan, Molecular Mechanism of Coordinating Cilia Intersection and Elongation, 23rd International C. elegans Conference, June 21-25, 2021.
Ahsen Konaç, Sebiha Çevik, Oktay I. Kaplan, Understanding the Molecular Basis of Aging of Sensory Neurons in C. elegans, 23rd International C. elegans Conference, June 21-25, 2021.
2020
B.Acar. EMBL Symposium: Organoids: Modelling Organ Development and Disease in 3D Culture, 21-24 October 2020. Kongre Katılım.
B.Acar. "Discovering Organoids: Intestinal&Cerebral” Course, CamBioScience, 4-5 June, 2020. Workshop Katılım.
Merve Şansaçar, Nihan Aktaş, E. Basak Gencer Akçok and Mona El Khatib, The Effect of Hedgehog Inhibition and Autophagy Modulation on the Proliferation and Survival of AML Cell Lines, 3rd International Eurasian Conference, Uluslararası Hakemli Kongre, Poster Sunum.
Merve Gül Turan, Sebiha Cevik, Oktay I. Kaplan, Characterization of the voltage-gated K+ channel, a novel cilia, in cilia biogenesis, 9th International Molecular Biology and Biotechnology, 06/12/2020.
Ahsen Konac, Sebiha Cevik, Oktay I. Kaplan Understanding the Molecular Basis of Neural Aging in C. elegans, 9th International Molecular Biology and Biotechnology, 06/12/2020.
Proteomic Profile of Metformin Treated Senescent Mesenchymal Stem Cell Secretome, M. B. Acar, S.Ayaz-Guner, N. Alessio, H. Guner, M. Karakukcu, U. Galderisi, S. Ozcan, US HUPO 16th Annual Conference, Seattle Washington , US, 8-11 March 2020 ePoster Sunum.
2019
A. Sen, H. Senol, O. Ozgun Acar, E. Kale, A. Dag, G. Topcu (2019) Synthesis and initial evaluation of efficacy of olean-12-en-28-ol, 3b-pentacosanoate for the symptomatic treatment of multiple sclerosis. FEBS Open Bio 9 (Suppl. 1): 74. doi:10.1002/2211-5463.12675
Kale, E., Sen, A. (2019) characterization of human CYP450 isozymes responsible for the in vitro oxidative metabolism of mesalamine used for colitis. CBU International Conference Proceedings 2019-Medicine and Pharmacy, Vol 7: (2019): https://doi.org/10.12955/cbup.v7.1450.
Elif Kale, Ozden Ozgun Acar, Hajarat Abilo Alfa, Işıl Gazioglu, Gulactı Topçu and Alaattin Sen (2019) Anti-inflammatory Effects of UA and OPC Isolated from Capparis ovata. Proceedings of the 7th International Congress of The Molecular Biology Association Of Turkey. Turkish Journal of Biology 43 (5), Suppl: 10.
Gurbet Çelik-Turgut, Alaattin Sen (2019) Cladribine induced apoptosis in glioblastoma cells. Proceedings of the7th International Congress of The Molecular Biology Association of Turkey. Turkish Journal of Biology 43 (5), Suppl: 11.
Şule Irmak, Aslı Semiz, Elif Kale, Fatma Sezer Şenol-Deniz, Ozden Ozgun Acar, Gabriela Tataringa, Ana-Maria Zbancioc, Krystyna Skalicka-Wozniak, Ilkay Erdogan Orhan, Alaattin Sen (2019). Investigation of the anti-alzheimer effect of novel coumarin derivative. Proceedings of the7th International Congress of The Molecular Biology Association of Turkey. Turkish Journal of Biology 43 (5), Suppl: 78.
Ozden Ozgun Acar, Elif Kale, Hatice Oruc, Isıl Gazioglu, Gulactı Topçu and Alaattin Sen (2019) Anticarcinogenic effect a novel alkaloid: 1H-indole-2-hydroxy, 3 carboxylic acid. Proceedings of the7th International Congress of The Molecular Biology Association of Turkey. Turkish Journal of Biology 43 (5), Suppl: 130.
Aysun Adan, Osman Oğuz. Ph+ Akut Lenfoblastik Lösemi'de Resveratrol Tarafından İndüklenen Büyüme İnhibisyonunda Seramid Metabolizmasının Rolü. IV. Experimental Hematology Congress with International Participation, 19-21 April, 2019, Novo Otel, Gaziantep (Sözlü).
Osman Oğuz , Aysun Adan. Resveratrol Targets Sphingolipid Metabolism and BCR-ABL in Ph+ Acute Lymphoblastic Leukemia to Induce Growth Inhibiton. 3rd International Conference on Natural Products for Cancer Prevention and Therapy 2019 (Oral Presentation), Proceedings 2019, 40, 3; doi:10.3390/proceedings2019040003,
Nur Şebnem Ersöz, Aysun Adan. Resveratrol Targets Sphingolipid Metabolism to Induce Growth Inhibition in FLT3 ITD Acute Myeloid Leukemia. 3rd International Conference on Natural Products for Cancer Prevention and Therapy 2019 (Oral Presentation), Proceedings 2019, 40, 4; doi:10.3390/proceedings2019040004
Aysun Adan. Resveratrol Induced Growth Inhibition in Human Ph+ Acute Lymphoblastic Leukemia By Modulation of Sphingolipid Mechanism. 13th World Congress on Polyphenol Applications (Oral Presentation), 30 September-1 October, Valetta, Malta
Osman Oğuz, Aysun Adan. Regulation of sphingolipid metabolizing enzymes and BCR-ABL in human Ph+ acute lymphoblastic leukemia by resveratrol. 7th International Congress of the Molecular Biology Association of Turkey, İstanbul, Türkiye, 27 - 29 September 2019, Poster Turk J Biol. 2019; 43(5 Suppl): 1–132.
Nihan Aktas, Emel Basak Gencer Akcok, Mona El Khatib, The Inhibition of Autophagy and Hedgehog Pathway Leads to a Decrease In The Proliferation of Cholangiocarcinoma, 7th International BAU Drug Design Congress, Uluslararası Hakemli Kongre, Poster Sunum.
Oktay I. Kaplan, Furkan Torun, Huseyin Guner, Sebiha Cevik, [PosterPresentation], 52nd The European Human Genetics Conference, Goteburg, Sweden, June 15-18
A. Murat, S. Ayaz-Guner, M.B. Acar, E. Gokduman, G. Dinç, A. Ulukılıc, M. Doğanay, S. Ozcan. Immunoproteomic Analysis of Acinetobacter baumannii Surface an Secreted Proteins, 7th International Congress of the Molecular Biology Association of Turkey, İstanbul, Türkiye, 27 - 29 September 2019, Poster Sunum. (PT131, MolBio2019 Abstract Book p.195)
Mustafa Pir, Sebiha Cevik, Oktay I. Kaplan, Functional characterization of Joubert Syndrome associated CEP41, [PosterPresentation], MolBiyoKon’19 7th International Congress of the Molecular Biology Association of Turkey, September 27-29, 2019
Betul Pir, Sebiha Cevik, Oktay I. Kaplan, CRISPR/Cas9 technology: Functional Characterization of Single Amino Acid Variants, [PosterPresentation], MolBiyoKon’19 7th International Congress of the Molecular Biology Association of Turkey, September 27-29,2019
Oktay I. Kaplan, Ferhan Yenisert, Mustafa S. Pir, Betul Pir, Betul Altunkaynak, Atiye Kilic, Sebiha Cevik, Functional characterisation of Joubert Syndrome associated CEP-41 and ARMC-9, [PosterPresentation], 22 th International C. elegans Meeting, Los Angeles USA, June 20-24
S. Ayaz-Guner, M.B. Acar, E. Gokduman, N. Alessio, U. Galderisi, S. Ozcan, Contact with Senescent Mesenchymal Stem Cells (MSCs) Modulate Secretome Composition of myeloma cells, 7th International Congress of the Molecular Biology Association of Turkey, İstanbul, Türkiye, 27 - 29 September 2019, Poster Sunum. (PT133, MolBio2019 Abstract Book p.197)
Oktay I. Kaplan, Sebiha Cevik, S. Sadik Oner, Huseyin Guner, Ferhan Yenisert, Betul Altunkaynak, Betul Pir, Mustafa Pir, Atiye Kilic, A Novel Bioinformatic Approach Identifies Previously Uncharacterized Ciliary Genes. 2019 Last BM1408 Action Meeting. Switzerland, March 20-22 , 2019.
2018
Aysun Adan, Osman Oğuz. Novel Combination of Resveratrol And Ceramide Metabolizing Enzymes Synergistically Enhances The Anti-Proliferative And Pro-Apoptotic Effects On Ph + Acute Lymphoblastic Leukemia. The 23rd Congress of EHA, 14-17 June 2018 (Published in abstract book).
Kentish JC., Martin-Garrido A., Biesiadecki BJ., Salhi HE., Shaifta Y., Dos Remedios CG., Ayaz-Guner S., Cai W., Ge Y., Avkiran M., P457:Monophosphorylation of cardiac troponin-I at Ser23/24 regulates cardiac myofibrillar Ca2+ sensitivity and modulates calpain-induced proteolysis. Fifth Congress of the ESC Council on Basic Cardiovascular Science Vienna, 20th – 22nd April 2018 Cardiovascular Research 114(suppl_1):S110-S110.
Ferhan Yenisert1, Betül Pir, Mustafa S. Pir, D. Atiye Kılıç, M. Betül Altunkaynak, Sebiha Çevik, Oktay I. Kaplan, Silya genlerinin C.elegans’ ta fonksiyonel olarak karakterize edilmesi , 4. Yaşam Bilimleri Kongresi, Kayseri, TURKEY, 23-25 Şubat, 2018.
2017
Osman Oğuz, Aysun Adan. Synergistic Cytotoxic Effects of Resveratrol in Combination with Ceramide Metabolizing Enyzmes in Ph + Acute Lymphoblastic Leukemia. 2nd International Conference on Natural Products for Cancer Prevention and Therapy 8-11 Kasım 2017 (Kayseri/TÜRKİYE) (Oral Presentation).
Aysun Adan, Yusuf Baran. Fisetin and hesperetin induced apoptosis and cell cycle arrest in chronic myeloid leukemia cells accompanied by modulation of cellular signaling. 11th World Congress on Polyphenols Applications: Vienna Polyphenols 2017.21-22 June, 2017, Austria, Vienna (Oral Presentation)
Sebiha Cevik, Enes Cicek, Ismail Gumustop, Oktay I. Kaplan. Hunt For Novel Genes Associated With Cilia Biogenesis/Ciliopathy. Innovation In Medicine Meetings 3, Gaziantep, TURKEY, May 11-13, 2017
Emine ARTAN, Enes ÇİÇEK, Sebiha ÇEVİK, Oktay İsmail KAPLAN. ''The characterization of CEP41, a recently identified Joubert syndrome gene, in cilia biogenesis International Molecular Biology Congress, Istanbul, Turkey, Sep 8-10, 2017.
Ferhan Yenisert, Betül Ateş, Sebiha Çevik, Oktay İsmail Kaplan. Functional characterization of novel ciliary genes in C. elegans’ International Molecular Biology Congress, Istanbul, Turkey, Sep 8-10, 2017.